Panthers star Jarome Luai has made an early return from injury, while the Cowboys have picked Scott Drinkwater to replace Tom Dearden at five-eighth.
Souths have axed a young gun after a forgettable performance last week, while Broncos star Kurt Capewell has overcome an ankle injury.
Anthony Griffin has picked Jayden Sullivan at hooker and Tyrell Sloan on the bench with two Dragons stars sidelined.