Both the Sea Eagles and Broncos have been hit with injury blows, with Jason Saab and Brendan Piakura set for sideline stints.
"Any time you see one of your real speed men pull up like that it's not ideal, obviously he'll get scans in Australia, we've got a long turnaround but it's probably doubtful he'll play in that Roosters game," Anthony Seibold said.
In the first Las Vegas clash, Saab pulled up lame in the closing minutes of the clash, grabbing at his hamstring.
The 23-year-old looked unsettled, grabbing at his leg whilst standing beyond the dead ball line in a horrible sight for Manly fans.