Queensland defeated NSW 18-14, ending their clean sweep hopes, with Lenarduzzi scoring a late decisive try.
Queensland have spoiled the NSW Blues dream of recording a clean sweep in the Origin arena with a dramatic 18-14 win in Newcastle.
Chelsea Lenarduzzi, who was overlooked in game one, was the hero for the visitors as she put the Maroons into the lead with just six minutes left on the clock.
Ali Brigginshaw sent a slick pass out to the lock to charge over the tryline and put the Blues in an unfavourable position in front of a home crowd.