The premiers flexed their muscle in a nine-try demolition of the Raiders and will look to keep the roll going when they host the Sea Eagles at Bluebet Stadium on Saturday.
With Nathan Cleary running the show and Brian To'o running for 235 metres the Panthers moved on quicky from the disappointment of a golden point loss to the Eels in Round 4 to take their record to 2-2 for the season.
The Sea Eagles also had their attack working in a free-flowing contest against the Knights in Mudgee but were forced to settle for a draw after 90 minutes of pulsating action.