The Titans and Rabbitohs are both coming off consecutive losses and will be hoping their Origin stars can play a role in helping them rebound.
Gold Coast had the bye in Round 13 to recharge the batteries after a narrow loss to the Bulldogs and a 20-point thumping at the hands of Newcastle, while Souths had a six-game winning streak halted by the Eels in Round 12 before going down to Canberra last weekend.
The absence of Latrell Mitchell, Cameron Murray and Jai Arrow on Origin duty left the Rabbitohs vulnerable to an ambush in Round 13 and that's precisely what occurred as the Raiders came from behind to snatch victory.