Roosters coach Trent Robinson is facing a major call on star centre Joey Manu ahead of his side's biggest game of the season.
The Raiders are sweating on the availability of fiery lock Corey Horsburgh and could be set for mass changes after a failed backline reshuffle last week.
Coach Ricky Stuart may be forced into making a tough decision on Jarrod Croker after the club legend only played three minutes off the bench last week.
Meanwhile, Nicho Hynes is set to return in a major boost for the Sharks. But it's not so good news for the Warriors, who have copped a fresh injury blow.