Zac Laybutt is out with a head injury; replacements include Rob Derby, Ronnie Philitoga, and Ethan King.
The Cowboys have been forced into a backline shuffle this week after left winger Zac Laybutt suffered a category 1 head knock during North Queensland's 24-10 triumph over the Tigers on Saturday night.
Laybutt will miss at least the round 27 clash with the Raiders, while Murray Taulagi has also been ruled out for the season.
Cowboys coach Todd Payten said there were three clear options when queried about Laybutt's replacement in the wake of Saturday's win.
"The options are Rob Derby, Ronnie (Philitoga) and Kingy (Ethan King). They're the first three that come to mind," Payten said.
"The first two have been playing really well in the Q Cup now for a little period, Ronny in particular.