Noah Martin has ankle injuries needing surgery; Zac Hosking is out indefinitely due to concussion protocol.
The Raiders have issued an injury update ahead of Saturday's clash with the Gold Coast.
Noah Martin suffered separate syndesmosis injuries to both ankles and will see a specialist on Friday ahead of planned surgery next week.
Zac Hosking has been ruled out of Saturday's match under the concussion protocol and is currently sidelined indefinitely.
Hosking will be assessed on a weekly basis to determine when he can safely return to training and match play.