The Dolphins face challenges without key players during Origin, while the Raiders adjust without Young and Strange.
The Dolphins are riding a three-game winning streak but must now navigate the Origin period without stars Hamiso Tabuai-Fidow, Max Plath, Selwyn Cobbo and Thomas Flegler.
With five-eighth Kodi Nikorima also suffering an injury against the Rabbitohs, coach Kristian Woolf will have to dig deep into his squad to roll out a team that can keep the roll going.
The Raiders, meanwhile, have edge forward Hudson Young and five-eighth Ethan Strange away on NSW Blues duty so they will also be forced to shuffle the deck.