Roosters centre Joseph Manu will sidelined for two to three weeks after suffering a grade two calf strain causing a big headache for Trent Robinson.
Storm forward Kenny Bromwich will need to pass concussion protocols, while a number of Souths guns will also be racing the club to return from head knocks.
Meanwhile, the Sharks could be without barnstorming centre Siosifa Talakai after an ugly hip-drop tackle from Knights prop Mat Croker.