Both sides will be looking to bounce back from disappointing losses last week but the Raiders will fancy their chances against a Rabbitohs side without Origin stars Latrell Mitchell, Cameron Murray and Jai Arrow.
Knocked off the top of the ladder after the Eels snapped their six-game winning streak, South Sydney will be hoping to get their season back on track when they host the eighth-placed Raiders at Accor Stadium.
Jason Demetriou's men are flying high with an 8-4 record this season but this may be their toughest test yet with Mitchell, Murray and Arrow called into Origin camps and centre Campbell Graham resting a sternum injury.